General Practice 2022

Sibutramine is bad for he alth?

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Sibutramine is bad for he alth?
Sibutramine is bad for he alth?

Sibutramine is a drug indicated as an aid in weight loss in people with a body mass index (BMI) greater than 30 kg/m2, after a rigorous evaluation by the doctor. This remedy works by increasing the levels of chemicals in the body, such as serotonin and noradrenaline, which act on neurons in the brain, but also acts on nerves in other parts of the body that control the functions of the cardiovascular system, which can bring benefits in weight loss., but it can also cause serious side effects.

Some studies [1, 2] show that sibutramine can be harmful to he alth, because due to its action on the cardiovascular system, this drug can cause a contraction of blood vessels blood pressure, and lead to an increase in heart rate and blood pressure, which can increase the risk of serious cardiovascular problems in people who are at risk for developing them.

For this reason, the sale of sibutramine was suspended in Europe and there was greater control over prescriptions in Brazil. Thus, this medication should only be used with medical advice, since its side effects can be serious and do not compensate for its slimming benefit. In addition, some studies indicate that, when discontinuing the medication, patients can return to their previous weight very easily and sometimes gain more weight, exceeding their previous weight.

The most serious side effects that can occur while using sibutramine are:

1. Increased risk of cardiovascular disease

Sibutramine is a drug that increases the risk of myocardial infarction, stroke, cardiac arrest and cardiovascular death, since its side effects are increased blood pressure and changes in heart rate.

2. Depression and Anxiety

In some cases, sibutramine use is also associated with the development of depression, psychosis, anxiety and mania, including suicide attempts.

3. Return to previous weight

Some studies indicate that, when discontinuing medication, many patients return to their previous weight very easily and sometimes gain even more weight, and may exceed the weight they had before starting sibutramine.

Other side effects that can be caused by this remedy are constipation, dry mouth, insomnia, headache, increased sweating and taste changes.

When to stop using sibutramine

The use of sibutramine should be stopped by the doctor in the following situations:

  • Changes in heart rate or clinically relevant increases in blood pressure;
  • Psychiatric disorders such as anxiety, depression, psychosis, mania or suicide attempt;
  • Weight loss of less than 2 kg after 4 weeks of treatment at the highest dose;
  • Weight loss after 3 months of treatment less than 5% compared to the initial one;
  • Stabilization of weight loss by less than 5% compared to initial;
  • Increase of 3 kg or more in body weight after previous loss.

In addition, treatment should not be longer than one year and frequent monitoring of blood pressure and heart rate should be performed.

Who should not use

Sibutramine should not be used in people with a history of major appetite disorders, psychiatric disorders, Tourette's syndrome, history of coronary heart disease, congestive heart failure, tachycardia, peripheral arterial occlusive disease, arrhythmias and cerebrovascular disease, hypertension uncontrolled, hyperthyroidism, prostate hypertrophy, pheochromocytoma, history of substance and alcohol abuse, pregnancy, lactation and elderly over 65 years of age.

How to take sibutramine safely

Sibutramine should only be used under a doctor's prescription, after a careful assessment of the person's he alth history and the doctor's completion of the disclaimer, which must be delivered to the pharmacy at the time of purchase.

In Brazil, sibutramine can be used by people who suffer from obesity, who have a BMI equal to or greater than 30, in addition to diet and physical activity.

Learn more information about sibutramine and understand its indications.

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