Table of contents:
- 1. Antiallergics
- 2. Antidepressants
- 3. Antipsychotics
- 4. Corticosteroids
- 5. Blood Pressure Remedies
- 6. Oral antidiabetics
Some drugs such as antidepressants, antiallergics or corticosteroids, especially when used long term, can cause side effects that, over time, can cause weight gain.
The causes of weight gain caused by these drugs are not yet fully understood, however, it is believed that in most cases they are related to increased appetite, fluid retention or the appearance of tiredness excessive that impairs the practice of physical activities.
Although they can cause weight gain, treatment with these drugs should not be stopped on their own, but first consult the doctor who prescribed them in order to assess the possibility of switching to another type or changing the dose.It is even possible that a drug that causes weight gain in one person may not do so in another, due to the different responses of the body.
The main remedies that can cause weight gain are:
Some antiallergics, such as cetirizine, fexofenadine or desloratadine, indicated for the treatment of allergy symptoms such as sneezing, stuffy nose, itchy eyes or skin, for example, can cause weight gain.
This happens because antiallergics work by reducing the effect of histamine, a substance released by the body responsible for allergy symptoms, but which also helps in the regulation and reduction of appetite. Thus, when a person takes an antiallergic, it blocks the action of histamine, which can lead to increased appetite and weight gain.
Furthermore, in the case of antiallergic drugs that cause sleep, such as hydroxyzine or clemastine, they may result in less willingness to exercise, which may also contribute to weight gain.
Antidepressants such as amitriptyline, nortriptyline, escitalopram, or paroxetine can cause weight gain during treatment, especially when used for a long period of time, as these drugs work by altering the levels or action of chemicals in the brain, such as serotonin, dopamine or histamine, causing increased appetite.
However, if the person begins to have weight problems, the doctor should be informed of the changes in weight so that the treatment can be reassessed and, if necessary, change the dose of the antidepressant or switch to another one, for example. You should never stop taking antidepressants on your own.
Some antidepressant options that do not cause weight changes are fluoxetine, bupropion or duloxetine, for example.
Antipsychotics are one of the types of medication most related to weight gain, however, the ones that usually have this side effect are atypical antipsychotics, such as olanzapine or risperidone, for example.
This effect happens because antipsychotics increase a brain protein known as AMPK, and when this protein is increased, it can block the effect of histamine, which is important for regulating the feeling of hunger.
However, antipsychotics are very important in the treatment of psychiatric disorders such as schizophrenia or bipolar disorder and therefore should not be discontinued without medical advice. Some antipsychotic options that typically have less risk of gaining weight are ziprasidone or aripiprazole.
Corticosteroids, such as prednisone, methylprednisolone or hydrocortisone, are drugs that are often used to relieve the symptoms of inflammatory diseases such as severe asthma or rheumatoid arthritis, for example, and when used for a long period of time, mainly orally, can cause the body to retain more s alt, which in large amounts in the body increases fluid retention, which leads to weight gain.
In addition, corticosteroids cause an increase in appetite and also affect metabolism and the way the body deposits fat, leading to an increase and redistribution of body fat, which can accumulate mainly in the abdomen, face and behind the body. neck, as in Cushing's Syndrome, which can also contribute to weight gain.
5. Blood Pressure Remedies
Although it is rarer, some drugs used to control blood pressure can also lead to weight gain, especially beta-blockers such as metoprolol or atenolol, for example.
This effect, although not caused by an increase in appetite, happens because a common side effect of beta-blockers is the appearance of excessive tiredness, which can lead the person to do less physical exercise, which increases the chances of gaining weight.
6. Oral antidiabetics
Oral antidiabetics used in the treatment of diabetes, such as glipizide, gliclazide or glibenclamide, stimulate the release of insulin by the pancreas, causing a sharp decrease in blood sugar that is carried into the cells of the body.This sugar inside the cells works as a source of energy, which, if not used by the body, is stored in the form of fat, which can cause weight gain.
Furthermore, when blood sugar levels are too low, it can make the body feel hungrier, to try to compensate for the lack of sugar, which can also cause weight gain.