General Practice 2022

Duloxetine (Cymb alta): what it is for, how to take it and side effects

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Duloxetine (Cymb alta): what it is for, how to take it and side effects
Duloxetine (Cymb alta): what it is for, how to take it and side effects
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Duloxetine is a drug, marketed under the name Cymb alta, indicated for the treatment of major depression, diabetic peripheral neuropathic pain, fibromyalgia, generalized anxiety disorder, chronic low back pain or osteoarthritis, for example.

This remedy can be found in pharmacies or drugstores, in the form of capsules containing 30 mg or 60 mg of duloxetine, and the dose and duration of treatment depend on the condition to be treated and medical advice.

Duloxetine is sold only by prescription and withholding by the pharmacy, and can also be found under similar names Velija, Cymbi or Dual, for example, or in generic form under the name Duloxetine Hydrochloride.

What is it for

Duloxetine is a drug indicated for the treatment of:

  • Major depressive disorder;
  • Diabetic peripheral neuropathic pain;
  • Fibromyalgia in people with or without major depressive disorder;
  • Chronic pain states associated with chronic low back pain or knee osteoarthritis;
  • Generalized Anxiety Disorder.

Duloxetine should always be used with medical indication and guidance according to the condition to be treated.

How to use

Duloxetine should be taken orally before or after a meal, at the dose and duration determined by the doctor.

Duloxetine dose may vary depending on the type of condition being treated and includes:

1. Major depressive disorder

The recommended starting dose is 60 mg of duloxetine once daily. In some cases, treatment may be started with a dose of 30 mg once a day for a week to allow the person to adapt to the medication, before increasing to 60 mg.

The dose of duloxetine may be increased by your physician to a maximum of 120 mg per day, divided into two doses of 60 mg.

Acute episodes of major depressive disorder require maintenance drug therapy at a dose of 60 mg, usually for several months or longer.

2. Diabetic peripheral neuropathic pain

The recommended starting dose is 60 mg of duloxetine once daily. However, the starting dose may be lower, depending on medical judgment and the person's tolerance for treatment.

3. Fibromyalgia

The recommended starting dose is 60 mg of duloxetine once daily.In some cases, it may be necessary to start treatment with a dose of 30 mg, once a day, for a week, so that the person adapts to the medication, before increasing the dose to 60 mg, as directed by the doctor.

4. Chronic pain associated with chronic low back pain or knee osteoarthritis

The recommended starting dose is 60 mg of duloxetine once daily, however, in some cases it may be necessary to start treatment with a dose of 30 mg daily for one week to facilitate treatment. adaptation to the medication, before increasing the dose.

The dose of duloxetine may be increased by your physician to a maximum of 120 mg per day, divided into two doses of 60 mg.

5. Generalized Anxiety Disorder

The recommended starting dose is 60 mg once a day, and in some cases the doctor may start treatment with a dose of 30 mg once a day for a week to allow adaptation to the medication, before increasing the dose to 60 mg.

In cases where the doctor deems it necessary, the dose may be increased to 60 mg, in increments of 30 mg, once a day, up to a maximum of 120 mg per day, as directed doctor.

Generalized anxiety disorder requires treatment for several months or even longer treatments. The drug should be administered at a dose of 60 to 120 mg once a day.

Possible side effects

The most common side effects that can occur during treatment with duloxetine are dizziness, nausea, constipation, loss of appetite, dry mouth or increased sweat production.

It is advised to discontinue use and seek medical help immediately or the nearest emergency department if symptoms of duloxetine allergy such as difficulty breathing, feeling of a closed throat, swelling of the mouth, tongue or face, hives, fever, burning sensation in the eyes, pain or blistering of the skin or peeling.Learn more about allergic reaction symptoms.

In addition, the doctor should be reported if the person has mood or behavior changes, anxiety, panic attacks, difficulty sleeping or impulsiveness, irritation, agitation, aggression, depression or thoughts of suicide.

Duloxetine slimming?

Duloxetine can lead to modest weight loss, especially in short-term treatment, due to its appetite loss side effect. However, some studies show that duloxetine can increase weight when treated long-term[1] These effects on body weight may vary from person to person.

Who should not use

Duloxetine should not be used by children under the age of 18, pregnant or breastfeeding women, or by people using monoamine oxidase inhibitor (MAOI) medicines such as moclobemide, tranylcypromine, isocarboxazid or phenelzine, for example, waiting at least 14 days after the end of treatment with monoamine oxidase inhibitors to start treatment with duloxetine.

This medication should also not be used by people who have a known allergy to duloxetine or any of the components of the formula.

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