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Diagnostic Tests 2023

Alanine Aminotransferase (ALT): what é and what does high TGP mean

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Alanine Aminotransferase (ALT): what é and what does high TGP mean
Alanine Aminotransferase (ALT): what é and what does high TGP mean

Alanine Aminotransferase Test, also known as or TGP, is a blood test that helps identify liver injury and disease due to the elevated presence of the enzyme alanine aminotransferase, also called of glutamic pyruvic transaminase in the blood, which is normally found between 7 and 56 U/L of blood.

The pyruvic transaminase enzyme is present inside the liver cells and, therefore, when there is an injury to this organ, caused by a virus or toxic substances, for example, it is common for the enzyme to be released into the bloodstream.

Testing of TGP is usually ordered in conjunction with the dosage of TGO, as it is possible to more accurately assess liver he alth. Learn more about TGO and TGP.


ALT too high

  • 10 times higher than normal: is usually a change caused by acute hepatitis caused by a virus or the use of some medications. See other causes of acute hepatitis.
  • 100 times higher than normal: is very common in users of drugs, alcohol or other substances that cause severe liver damage.

elevated ALT

  • 4 times higher than normal: may be a sign of chronic hepatitis and, therefore, may indicate liver disease such as cirrhosis or cancer, for example.

Although it is a very specific marker for liver damage, this enzyme can also be found in the muscles and heart in smaller amounts, and an increase in the concentration of this enzyme in the blood can be observed after intense physical exercise, for example.

Therefore, to assess the functioning and identify liver damage, the doctor may request the measurement of other enzymes, such as lactate dehydrogenase (LDH) and AST or TGO. Learn more about the AST exam.

What to do in case of high "Image" alt="

In cases where the pyruvic transaminase test has a high value, it is recommended to consult a hepatologist to evaluate the person's clinical history and identify what may be the cause of the liver change. The doctor may also order other more specific tests such as hepatitis tests or liver biopsy to confirm the diagnostic hypothesis.

Furthermore, in cases of high "Image" it is also advisable to eat a diet suitable for the liver, low in fat and giving preference to cooked foods. Learn how to diet for the liver.

What can be low TGP

Decrease in TGP levels alone is usually not relevant, especially when there are no signs or symptoms. However, when there is also a decrease in the level of TGO, it can be indicative of azotemia, which is a situation characterized by the accumulation of urea and creatinine in the blood, be indicative of urinary tract infection or liver cancer, and it is important that more exams are performed.

When to take the ALT exam

The alanine aminotransferase test is used to detect liver damage and, therefore, may be recommended for people who have:

  • Liver fat or overweight;
  • Excessive fatigue;
  • Loss of appetite;
  • Nausea and vomiting;
  • Swelling of the belly;
  • Dark urine;
  • Yellow skin and eyes.

However, levels of can already be high even when the patient does not have any symptoms, being a great tool for early diagnosis of liver problems. Thus, the "Image" test can also be performed when there is a history of exposure to the hepatitis virus, excessive use of alcoholic beverages or the presence of diabetes. Learn what other blood test changes mean. alt="

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