General Practice 2022

SíGoodpasture's syndrome: what é, symptoms, causes and treatment

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SíGoodpasture's syndrome: what é, symptoms, causes and treatment
SíGoodpasture's syndrome: what é, symptoms, causes and treatment

Goodpasture Syndrome is a rare autoimmune disease, in which the body's defense cells attack the kidneys and lungs, mainly causing symptoms such as coughing up blood, difficulty breathing and blood loss in the urine.

This syndrome happens due to the presence of antibodies that attack the cells of the kidneys and lungs. Some factors that seem to increase the risk of developing this disease are: having a history of the disease and also smoking, having recurrent respiratory infections and being exposed to the inhalation of substances such as methane or propane, for example.

Treatment is based on the use of medications such as immunosuppressants and corticosteroids, but in more severe cases, plasmapheresis or hemodialysis may be necessary.

Main symptoms

The main symptoms of Goodpasture Syndrome are:

  • Excessive fatigue;
  • Cough with blood;
  • Difficulty breathing;
  • Pain when breathing;
  • Increased blood urea levels;
  • Presence of blood and/or foam in the urine;
  • Burning when urinating.

When symptoms appear, it is recommended to seek medical attention quickly for examinations and indication of the most appropriate treatment, as symptoms can worsen if the disease is not treated early.

In addition, other diseases may have symptoms very similar to those of this disease, such as Wegener's granulomatosis, which makes diagnosis difficult. Learn about the symptoms and how to treat Wegener's granulomatosis.

How to confirm the diagnosis

To diagnose Goodpasture syndrome, the doctor will evaluate your he alth history and the duration of symptoms. Then, the doctor may order some tests, such as blood and urine, to identify the antibodies produced by the body that cause Goodpasture syndrome.

as a kidney biopsy, which is the removal of a small part of the tissue from the kidneys, to find out if there are cells that cause Goodpasture syndrome.

In addition, the doctor may also order other tests, such as a kidney biopsy, which consists of removing a small part of the kidney tissue that will be evaluated in the laboratory, in order to see if there are cells that cause the syndrome from Goodpasture.

X-ray and CT scan may also be ordered by the doctor to detect lung damage. See more details on how computed tomography is performed.

Possible causes

The cause of Goodpasture syndrome is due to anti-GBM antibodies that attack the NC-1 part of type IV collagen in kidney and lung cells.

This syndrome appears to be more common in men than women, between the ages of 20 and 30, and in people with lighter skin. In addition, exposure to chemicals such as pesticides, cigarette smoke and infections caused by viruses are other factors that seem to increase the risk of developing the syndrome, as they can cause the body's defense cells to attack the lungs and lungs. kidneys.

How the treatment is done

Treatment of Goodpasture Syndrome is usually done in hospital and is based on the use of immunosuppressive drugs and corticosteroids, which prevent the body's defense cells from destroying the kidneys and lungs.

In some cases, treatment by plasmapheresis is indicated, which is a procedure that filters the blood and separates antibodies that are harmful to the kidney and lung.If the kidneys have been severely affected, hemodialysis or a kidney transplant may be necessary. Understand better what plasmapheresis is and how it is done.

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