General Practice 2022

Bromopride: what it is for, how to take it and side effects

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Bromopride: what it is for, how to take it and side effects
Bromopride: what it is for, how to take it and side effects

Bromopride is an antiemetic and prokinetic drug indicated for the treatment of nausea and vomiting or changes in gastrointestinal movements, which acts by blocking the effect of dopamine, a type of neurotransmitter with action in the gastrointestinal system and in the brain, which causes nausea and vomiting related to surgery or gastroesophageal reflux, for example.

This medicine can be found in pharmacies or drugstores in the form of capsules, tablets or drops, with the trade name Digesan, in the form of generic with the name Bromopride or with similar names Plamet or Fagico, for example. In addition, bromopride can also be found in the form of injection for application into the muscle or injection directly into the vein, being used only in hospitals, under the supervision of a he althcare professional.

Bromopride can be used by adults or children over 1 year of age, and must be used with medical advice and guidance.

What is it for

Bromopride is indicated for the treatment or prevention of nausea and vomiting, changes in stomach and bowel movements, and to relieve symptoms caused by gastroesophageal reflux, as it acts by blocking the effect of dopamine on the brain and gastrointestinal system, in addition to increasing gastric emptying and intestinal transit. Know how to identify the symptoms of gastroesophageal reflux.

In addition, bromopride can also be used during radiological examinations.

How to take it

The way to use bromopride depends on the presentation of the drug and includes:

1. Bromopride Pediatric Drops 4 mg/mL

Pediatric drops bromopride contains 4 mg of bromopride in every 1 mL of solution, sold in a 20 mL bottle, and must be taken orally.

The recommended dose for children over 1 year of age is 1 to 2 drops per kg of body weight, up to three times a day, as directed by the pediatrician.

2. Bromopride oral solution 1 mg/mL

Bromopride oral solution contains 1 mg of bromopride for every 1 mL of solution, and is sold in 120 mL bottles.

Doses must be taken orally and vary by age:

  • Adults: The recommended dose for adults is 10 mL of oral solution, which corresponds to 10 mg of bromopride, taken every 8 or 12 hours, according to the doctor's recommendation. The maximum dose per day should not be more than 60 mg;
  • Children over 1 year: the recommended dose for children is 0.5 to 1 mg per kg of body weight, per day, divided into 3 daily doses.

The duration of treatment with bromopride oral solution should be individually guided by the doctor.

3. Bromopride 10 mg tablet or capsules

Bromopride, in the form of tablets or capsules of 10 mg, must be taken orally, being indicated only for adults.

The recommended dose is 1 tablet or 10 mg capsule every 8 or 12 hours, as directed by your doctor. The maximum dose per day should not be more than 60 mg.

4. Injectable bromopride 10 mg/2 mL

Bromopride Injectable 10 mg/2mL should be applied directly into the vein or muscle of the arm or gluteal, by a physician, nurse or trained he althcare professional, and the dose should be determined by the physician according to the disease to be treated.

Generally, the recommended doses for injectable bromopride are:

  • Adults: the recommended intravenous or intramuscular dose is 1 to 2 ampoules per day;
  • Children over 1 year: The recommended dose is 0.5 to 1 mg per kg of body weight, daily, intramuscularly or into a vein.

These doses may be changed by your doctor, depending on the severity of nausea and vomiting or gastroesophageal reflux symptoms.

Possible side effects

The most common side effects that can occur during treatment with bromopride are restlessness, drowsiness, excessive tiredness, decreased strength or exhaustion.

Although more rare, tremors, muscle contractions, difficulty walking, slowed movement, agitation, seizures, insomnia, headache, dizziness, nausea, excessive or inadequate milk production, breast enlargement in men, blistering of the skin and intestinal disorders.

In addition, bromopride can cause severe allergic reactions that require immediate medical attention. Therefore, you should stop treatment and seek the nearest emergency department if you experience symptoms such as difficulty breathing, chest pain, feeling of a closed throat, swelling in the mouth, tongue or face, or hives.Know how to identify the symptoms of a severe allergic reaction.

In the case of injectable bromopride, as it is used in hospitals in the event of an allergic reaction, treatment is immediate.

Who should not use

Bromopride should not be used by children under 1 year of age, by pregnant or breastfeeding women, or by people who have gastrointestinal bleeding, obstruction or perforation, epilepsy or pheochromocytoma.

Furthermore, this drug should not be used by people who are allergic to bromopride or who are being treated with other antiemetics such as metoclopramide, ondansetron, or drugs such as haloperidol, chlorpromazine, risperidone, cinnarizine or fluoxetine, citalopram or sertraline, for example.

It is important to inform the doctor about all the medicines that the person uses, as bromopride can reduce the effect of digoxin used in the treatment of heart diseases, or increase the action of paracetamol, tetracycline or levodopa, which may cause intoxication or effects serious side effects.

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