Bulas and Medicines 2022

Prednisolone: ​​what it is for, how to take it and side effects

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Prednisolone: ​​what it is for, how to take it and side effects
Prednisolone: ​​what it is for, how to take it and side effects
Anonim

Prednisolone is an anti-inflammatory steroid, indicated for the treatment of problems such as rheumatism, hormonal changes, collagenosis, infections, allergies and skin and eye problems, as well as being used in the treatment of cancer.

This medication is available in the form of tablets, oral suspension or drops and can be purchased at pharmacies, upon presentation of a prescription.

The use of prednisolone should always be done according to the doctor's recommendation, as the prolonged and improper use of this medication can lead to the appearance of side effects, such as increased cholesterol and triglycerides, for example.

What is it for

Prednisolone is used to treat inflammatory and autoimmune diseases such as:

  • Endocrine changes, such as adrenocortical insufficiency, congenital adrenal hyperplasia, non-suppurative thyroiditis, and cancer-associated hypercalcemia;
  • Rheumatism, such as psoriatic or rheumatoid arthritis, ankylosing spondylitis, bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis, osteoarthritic synovitis, and epicondylitis;
  • Collagenosis, in particular cases of systemic lupus erythematosus and acute rheumatic carditis;
  • Skin diseases, such as pemphigus, some dermatitis, mycoses and severe psoriasis;
  • Allergies, such as allergic rhinitis, contact and atopic dermatitis, serum sickness, and drug hypersensitivity reactions;
  • Ophthalmic diseases, such as allergic corneal marginal ulcers, ophthalmic herpes zoster, anterior segment inflammation, choroiditis and diffuse posterior uveitis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, chorioretinitis, optic neuritis, iritis and iridocyclitis;
  • Respiratory diseases, such as symptomatic sarcoidosis, Löefler syndrome, berylliosis, some cases of tuberculosis, aspiration pneumonitis and bronchial asthma;
  • Blood disorders, such as idiopathic thrombocytopenic purpura and secondary thrombocytopenia in adults, acquired hemolytic anemia, erythrocytic anemia, and erythroid anemia;
  • Cancer, in the palliative treatment of leukemias and lymphomas.

Furthermore, prednisolone can also be used for the treatment of acute exacerbations of multiple sclerosis, to reduce swelling in cases of idiopathic nephrotic syndrome and lupus erythematosus, and for the maintenance of the patient who has suffered from ulcerative colitis or enteritis. regional.

How to take it

Prednisolone dosage varies greatly depending on weight, age, disease to be treated and pharmaceutical form and should always be determined by the doctor.

1. 5 or 20 mg tablets

  • Adults: the starting dose ranges from 5 to 60 mg per day, equivalent to 1 tablet of 5 mg or 3 tablets of 20 mg.
  • Children: the starting dose ranges from 5 to 20 mg per day, equivalent to 1 tablet of 5 mg or 1 tablet of 20 mg.

The dosage should be reduced gradually when the drug is administered for more than a few days. The tablets should be swallowed whole, together with a glass of water, without breaking or chewing.

2. Syrup 3 mg/mL or 1 mg/mL

  • Adults: the recommended dose ranges from 5 to 60 mg per day;
  • Infants and Children: the recommended dose ranges from 0.14 to 2 mg per 1 kg of child weight, per day, divided into 3 to 4 daily administrations;

The volume to be measured depends on the concentration of the oral solution, as there are two different presentations. Dosage should be reduced gradually when the drug is administered for more than a few days.

3. Solution in drops of 11 mg/mL

  • Adults: The recommended dose ranges from 5 to 60 mg per day, equivalent to 9 drops or 109 drops, per day.
  • Children: The recommended dose ranges from 0.14 to 2 mg for every 1 kg of a child's weight, given 1 to 4 times a day.

Each drop is equivalent to 0.55 mg of prednisolone. Dosage should be reduced gradually when the drug is administered for more than a few days.

The recommended dose and duration of treatment with Prednisolone should be indicated by the physician, as these depend on the problem being treated, age and individual patient response to treatment.

Possible side effects

The most common side effects that may occur during treatment with prednisolone are increased appetite, poor digestion, peptic ulcer, pancreatitis, ulcerative esophagitis, nervousness, fatigue, and insomnia.

In addition, allergic reactions, changes in the eyes such as cataracts, glaucoma, exophthalmos and intensification of secondary infections by fungi or viruses of the eyes, reduced carbohydrate tolerance, manifestation of latent diabetes mellitus and increased needs may occur. of insulin or oral hypoglycemic agents in diabetics.

Treatment with high doses of corticosteroids can induce a marked increase in blood triglycerides. See more about the side effects of corticosteroids.

Who should not take it

Prednisolone is contraindicated for people with systemic fungal infections or uncontrolled infections and for patients allergic to prednisolone or any of the components of the formula.

Furthermore, this medication should not be used by pregnant or breast-feeding women unless recommended by a doctor.

What is the difference between prednisolone and prednisone?

Prednisone is a prodrug of prednisolone, that is, prednisone is an inactive substance, which, in order to become active, needs to be transformed in the liver into prednisolone to exert its action.

Thus, if the person ingests prednisone or prednisolone, the action exerted by the drug will be the same, since prednisone is transformed and activated, in the liver, into prednisolone. For this reason, prednisolone is more beneficial for people with liver problems, as it does not need to be transformed in the liver to be active in the body.

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