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2023 Author: Benjamin Dyson | [email protected]. Last modified: 2023-05-21 01:37
Dipyrone, also known as dipyrone monohydrate or dipyrone sodium, is an analgesic and antipyretic remedy, which acts by reducing the production of substances in the body responsible for causing pain or fever and, therefore, is indicated to lower fever. and relieve pain, usually caused by colds and flu, for example.
This remedy can be found in pharmacies or drugstores in the form of drops, pills, syrup or suppositories, under the trade name Novalgina, in the generic form as dipyrone monohydrate or dipyrone sodium, or with similar names Anador, Maxalgina, dip lyser, Magnopyrol or Dipimed, for example and should always be used with medical indication and guidance.
Dipyrone can also be found in the form of an injection, applied directly into a vein or muscle, made in the hospital, he alth center or pharmacy, by a nurse or a he alth professional, according to the medical indication.
What is it for
Dipyrone is indicated for the treatment of pain and fever in adults, adolescents, children or babies over 3 months of age. See how to identify and measure fever in children and adults.
This remedy begins to work in the body in approximately 30 to 60 minutes after administration, and its effect lasts for about 4 hours.
How to use
How to use dipyrone depends on the presentation and includes:
1. Dipyrone single tablet of 500 mg and 1 g
Dipyrone tablet can be used by adults or adolescents over 15 years of age, and must be taken orally, with a glass of water.
The form of use varies with the dose of the tablet and includes:
- Dipyrone 500 mg: 1 to 2 tablets, up to 4 times a day, that is, every 6 hours;
- Dipyrone 1 g: half to 1 tablet, up to 4 times a day, that is, every 6 hours.
Treatment time should be guided by the doctor, and should not exceed the maximum recommended dose.
2. Dipyrone 1 g effervescent tablet
The dipyrone effervescent tablet must be dissolved in half a glass of water and drunk immediately after preparation, and can be used by adults and adolescents over 15 years.
The recommended dose is 1 effervescent tablet of 1 g, up to 4 times a day, that is, every 6 hours, or according to medical advice.
3. Dipyrone drops 500 mg/mL
Dipyrone drops of 500 mg/mL should be used orally, being indicated for children or babies over 3 months of age. Children under 3 months of age or weighing less than 5 kg should not be treated with dipyrone.
This medication can be administered 4 times a day, that is, every 6 hours, or according to medical advice, and should not exceed the maximum dose per day.
The recommended dose of dipyrone drops of 500 mg/mL depends on the weight of the child, following the guidelines in the following schedule:
|
Baby or child weight (age range) |
Number of drops |
Total maximum dose per day |
|---|---|---|
|
5 to 8 kg (3 to 11 months) |
2 to 5 drops, 4 times a day | 20 drops (4 servings of 5 drops) |
|
9 to 15 kg (1 to 3 years) |
3 to 10 drops, 4 times a day | 40 drops (4 servings of 10 drops) |
|
16 to 23 kg (4 to 6 years) |
5 to 15 drops, 4 times a day | 60 drops (4 servings of 15 drops) |
|
24 to 30 kg (7 to 9 years old) |
8 to 20 drops, 4 times a day | 80 drops (4 servings of 20 drops) |
|
31 to 45 kg (10 to 12 years) |
10 to 30 drops, 4 times a day | 120 drops (4 servings of 30 drops) |
|
46 to 53 kg (13 to 14 years) |
15 to 35 drops, 4 times a day | 140 drops (4 servings of 35 drops) |
For adolescents over 15 years and adults, doses of 20 to 40 drops, administered 4 times a day, are recommended.
4. Dipyrone Syrup 50 mg/mL
Dipyrone syrup or oral solution of 50 mg/mL must be administered orally using the dosing syringe provided in the package to measure the volume of the medicine that must be administered according to the weight of the child or baby with more than 3 months old. This medicine should not be used by babies younger than 3 months old or weighing less than 5 kg.
The dose of dipyrone syrup or oral solution of 50 mg/mL can be administered 4 times a day, that is, every 6 hours, or according to medical advice, not exceeding the maximum total dose per day.
The recommended doses of dipyrone syrup or 50mg/mL oral solution are:
|
Baby or child weight (age range) |
Volume to be measured in the dosing syringe |
Total maximum dose per day |
|---|---|---|
|
5 to 8 kg (3 to 11 months) |
1, 25 to 2.5 mL, 4 times a day | 10 mL (4 doses of 2.5 mL) |
|
9 to 15 kg (1 to 3 years) |
2, 5 to 5 mL, 4 times a day | 20 mL (4 doses of 5 mL) |
|
16 to 23 kg (4 to 6 years) |
3.75 to 7.5 mL, 4 times a day | 30 mL (4 servings of 7.5 mL) |
|
24 to 30 kg (7 to 9 years old) |
5 to 10 mL, 4 times a day | 40 mL (4 doses of 10 mL) |
|
31 to 45 kg (10 to 12 years) |
7, 5 to 15 mL, 4 times a day | 60 mL (4 doses of 15 mL) |
|
46 to 53 kg (13 to 14 years) |
8.75 to 17.5 mL, 4 times a day | 70 mL (4 servings of 17.5 mL) |
For adolescents over 15 years and adults, doses between 10 or 20 mL, 4 times a day are recommended.
5. Dipyrone 300 mg suppository
Dipyrone suppository should be applied rectally or anally, in children over 4 years of age or weighing more than 16 kg, and the recommended dose is to apply 1 suppository, up to a maximum of 4 times per day, that is, 1 suppository can be applied every 6 hours.
Before applying the suppository to the child, wash your hands with soap and water and, if possible, disinfect with alcohol. Then open the envelope with the suppository and remove the suppository from the package. With the thumb and forefinger, the buttocks should be pulled apart and the suppository introduced into the anal orifice. Then, gently press one buttock against the other for a few seconds to prevent the suppository from coming back.
Treatment time with suppository dipyrone must be done with pediatrician guidance.
6. Injectable dipyrone
Injectable dipyrone can be administered directly into a vein or muscle, by a nurse or other he althcare professional knowledgeable in injectable administration and always under medical supervision.
To apply directly into the vein, it is recommended that the person is lying down and the application must be very slow, at an infusion rate that does not exceed 1 mL, which corresponds to 500 mg of dipyrone, per minute, to avoid sudden drop in blood pressure.
The recommended dose in adults and adolescents over 15 years is 2 to 5 mL in a single dose, up to a maximum dose of 10 mL per day. For children under 1 year of age, injectable dipyrone should only be used for muscle application.
In children and infants, the recommended dose depends on weight, as shown in the following table:
|
Weight |
Dose (in mL) |
|---|---|
|
Babies from 5 to 8 kg |
0.1 to 0.2 mL (applied to muscle only) |
|
Children from 9 to 15 kg |
0.2 to 0.5 mL (applied to muscle or vein) |
|
Children from 16 to 23 kg |
0.3 to 0.8 mL (applied to muscle or vein) |
|
Children from 24 to 30 kg |
0.4 to 1.0 mL (applied to muscle or vein) |
|
Children from 31 to 45 kg |
0.5 to 1.5 mL (applied to muscle or vein) |
|
Children from 46 to 53 kg |
0.8 to 1.8 mL (applied to muscle or vein) |
Injectable dipyrone should not be used by babies under 3 months of age.
Possible side effects
Some of the side effects that may occur during treatment with dipyrone are stomach or intestinal pain, poor digestion or diarrhea, red coloring of the urine, low blood pressure, cardiac arrhythmias, burning or hives on the skin.
Dipyrone can cause severe allergic reactions or anaphylactic shock that require immediate medical attention. Therefore, you should stop treatment and seek the nearest emergency department if you experience symptoms such as difficulty breathing, coughing, swelling in the mouth, tongue or face, redness or blistering of the skin. Know how to identify the symptoms of an allergic reaction.
In addition, one of the serious side effects that can occur with the use of dipyrone, and which must also be treated immediately by the doctor, is agranulocytosis, which is a decrease in the amount of white blood cells that participate in the body's defense against infections. This condition can be perceived through symptoms such as the formation of sores in the mouth, fever, chills, prostration in which the adult or child may have a soft body or slow movements, being recommended to take the child or go to the hospital immediately, because agranulocytosis can put your life at risk.
Who should not use
Dipyrone should not be used by people with impaired bone marrow function or diseases related to the production of blood cells, or who have developed allergic reactions after using pain or fever medication such as acetylsalicylic acid, paracetamol, diclofenac, ibuprofen, indomethacin and naproxen, for example.
In addition, dipyrone should not be used by people who are allergic or intolerant to dipyrone or any of the components of the formula, or medicines such as propynone, propyphenazone, phenylbutazone or oxyphenbutazone, for example.
Dypyrone drops, syrup or injection should not be used by children under 3 months. Dipyrone in the form of suppositories should not be used by children under 4 years of age, and dipyrone tablets should not be used by adolescents under 15 years of age.
This drug should also not be used by people with acute intermittent hepatic porphyria or congenital glucose-6-phosphate dehydrogenase deficiency.
